Abstract: This paper introduces a design scheme of coal mine wireless safety monitoring system based on TRF6900. The design realizes safety monitoring information collection through underground sensor module which is made up by TRF6900 and MSP430F149. In the meantime, it uses TRF6900 wireless transceiver chip and DSP430F149 SCM to construct the underground monitoring sub-station to convergence all monitoring information of branch roadway, and eventually realizes the data transmission to data monitoring center through RS485 bus and accomplishes the effective management of the safety monitoring datum.