Abstract: There were 5 mining faces and 13 heading faces in Zhaojiazhai Coal Mine, due to the layout of production mining area concentrated, it did not realize coal mine partition ventilation. Aiming at the problem of coal mine ventilation system, through scheme comparation, it determined coal mine ventilation system optimization scheme. It changed ventilation network by using the existing roadway and designing new roadway, thus achieved coal mine partition ventilation. This scheme not only solved the problem of mine partition ventilation, but also relieved the wind speed overrun problem of return air uphill, provided a guarantee for the coal mine safety production.