Abstract: The borehole pressure relief is one of the pressure-relieving methods of rock burst prevention. The results of borehole pressure relief are under the impact of borehole depth, borehole diameter, borehole angle and its collocation. The paper makes numerical simulation study based on orthogonal test design and analyzes the simulation results with multi-parameter and equilibrium theory. And then the paper obtains the influence principles of borehole depth, borehole diameter and borehole angle on borehole pressure relief. The borehole with 133 mm diameter and the angle of up-borehole and low-borehole with 15 and 8 respectively have good effects. These results correspond with local mining condition.