Abstract: There is a complex dynamic coupling field due to the interaction of open-pit mining and underground mining. In order to solve the stability problem of loess slope under the coupling of combined open-pit with underground mining, taking Anjialing open-pit as an engineering background, taking Geo-Slope software as plate, using Morgenstern-Price method to make stability analysis and evaluation for typical profile, the conclusion that slope stability coefficient is smaller than safety reserve coefficient, and the deformation and failure prevention measures and recommendations are proposed.