Abstract: In order to solve the problem of large deformation of surrounding rock in gob-side entry retaining in fully mechanized coal seam with large buried depth, taking the 182605 working face of Wutongzhuang Coal Mine as the engineering background, through field investigation, theoretical analysis and scheme design, a combined control technology system of “roadway advanced reinforcement support + roof cutting pressure relief blasting technology + high water material gob-side entry retaining support” is proposed, and the feasibility of the scheme is verified by field measured data. The engineering practice shows that after the implementation of the combined control support system, the deformation of the surrounding rock of the roadway has played an effective control role. When the cut-off distance is 293 m from the open-off cut of the working face, the convergence of two-side and the roof and floor convergence increase first and then decrease gradually, and finally tend to be stable. The damaged single hydraulic point column only accounts for 4.1%; the technology has been successfully implemented to retain 640 m roadway along goaf, and roadway deformation is controlled within the allowable deformation range, and the overall roadway retention effect is good.