Abstract: In order to solve the problems of the conventional coal mine gas drainage, such as unitary way, poor controllability, and low drainage efficiency, it put forward the new gas drainage way- pulsating gas drainage. The positive pressure was used based on the negative pressure drainage within a certain period, the positive pressure and the negative pressure was used interchangeably. The positive pressure damaged coal fracture and promoted the gas seepage, then negative pressure was used to carry out gas drainage. Through the field application of Guqiao Coal Mine, the gas drainage efficiency was improved obviously in high gas and low permeability coal seam. The results showed that the gas drainage efficiency could be increased by 40%, gas outburst was also prevented and drainage time was prolonged with pulsating gas drainage.