Abstract: To control and utilize the natural wind pressure of deep mine effectively, site measurement and simulation is used to study changing laws of natural wind pressure of Liangbaosi No.2 Coal Mine, meanwhile, the main affected area of natural wind pressure is determined through combination of qualitative and quantitative analysis. The results show that annual variation shaped of natural wind pressure of deep mine like a sine curve, which reaches maximum in winter and minimum in summer and the wind caused by natural wind pressure is consistent with mechanical ventilation. Natural wind pressure changes little during a day and the influence on ventilation system can be ignored. Among branches in response to natural wind pressure, the smaller consumption of mechanical power, the sensitivity of the branch is higher and stability of wind is poor. The mainly affected area of natural wind pressure distribute in neighboring region around the main and auxiliary shaft and air shaft.