Abstract: Liquid nitrogen infusion technology is an important technical for preventing and dealing with large-scale coal mine fire accidents. Qualitative analysis of the coal fire prevention mechanism of liquid nitrogen was obtained by Damkohler standards. Typical cases of industrial fire prevention trials of liquid nitrogen infusion technology were described. Technical parameters of perfusion, pipeline pressure drop, and outlet location were quantitatively discussed. Development tendency of coal mine liquid nitrogen fire prevention was proposed in this article. Strengthening basic research, considering key technologies and paying more attention to anti-fire system security, more safety, efficient and stable fire prevention system of liquid nitrogen infusion will be guaranteed.