Abstract: In order to improve the effectiveness of the gas explosion accident treatment and to reduce the loss of the gas explosion, through the analysis of several gas explosion accidents, combined with the characteristics of gas explosion, the gas explosion accident treatments were investigated actively and effectively, the basic principles of the gas explosion accident treatment were proposed, such as "unified command, responsibility and good order", "ascertaining disasters, scientific analysis, decisive decision-making", "people-oriented, safe rescue, executive in place", and three main technical points were discussed, including "whether or not cutting off the power supply immediately", "building ventilation condition, eliminating harmful gas", "ventilation recovery, setting up the rescue channel" during the gas explosion accidents treatment. On this basis, the effectiveness of gas explosion accident treatment principles and main technical points for gas explosion accident treatment was verified by the accident rescue case.