Abstract: Aiming at the problem that the low level understanding of coal reservoir permeability changes under mining influence has a direct impact on coal-bed methane ground drainage of mining area, we conducted a study on coal seam permeability change characteristics under mining influence in Huainan and Huaibei Mining Area as the object through the analysis of a large number of coal seam gas drainage data of mining areas combined with field monitoring results and the numerical simulation technology. The scope and boundary conditions of the gas wells under the mining influence are determined, and the change laws of permeability of the coal seam is revealed, and the relationship between the permeability of the coal seam and the advancing distance under the mining influence is established.