Abstract: In order to research seepage laws in low permeability and high storage coal seam through injecting heat, through laboratory tests, it was concluded that critical threshold temperature was 350 ℃ when the permeability of 3# coal seam of Shanxi Xucun Coal Mine happened great changes under temperature effect; thermal-fluid-solid mathematical model of injecting heat in low permeability coal seam is concluded through the theoretical analysis; based on this model, numerical simulation is used to study seepage regulation of low permeability and high storage coal seam through injecting heat under the action of heat-fluid-solid coupling. The results show that with the increase of injection time, coal seam permeability is increasing, when the injection time is 5 h, the coal seam permeability increases about 14 times than the original permeability, thermal effect is obvious, and thermal injection has little effect on change of coal seam permeability after 5 h.