Abstract: Under the influence of underground mining activities, the water conducted zone can not penetrate the aquifer. So, if the large well method is used to directly calculate the water inflow, the error will become greater. In this case, the complicated geological conditions are reasonably generalized and the hydro-geological conceptual model is established. The aquifer is divided into two parts which are not affected by each other in the vertical direction. The top and lateral water yield is calculated respectively. This method is more close to the actual situation. The corresponding mathematical model is obtained by combining the related theories. Combined with the field data of two working faces in Tingnan Mine and Hujiahe Mine of Binchang Mining Area, the result is more accurate by using the method to calculate the water inflow and comparing with the actual amount of water. This proves the rationality about the inverted partial penetrating large well method under the influence of mining below the thick aquifer.