Abstract: In order to form the corresponding well pattern in the coal mine preparation area and the planning area, the CBM-SIM coalbed methane numerical simulation software is used to launch history matching by selecting the coalbed methane development test well in Lishu Coal Mine, and the reservoir parameters are optimized and corrected to achieve the accurate characterization of the reservoir. In the background of the straight wells and the rectangular well pattern, based on the comprehensive consideration of fracturing scale and production requirement, setting up 7 kinds of well spacing, the CBM-SIM software was used to simulate the gas production for 15 years in different well groups, and the dynamic change value of gas content for 5 years. The results show that the optimal spacing is 200 m × 250 m and 300 m × 300 m respectively in the preparation area and the planning area. This conclusion can provide a reference for the development of ground coalbed methane in Lishu Coal Mine and the deep thin seam area in the northeast of China.