Abstract: For the problem of low efficiency of dust suppression by spraying of dewatering dust in coal mine, and to improve the effect of dust suppression by spraying, after studying the actual conditions of mine and coal dust, four chemical de-dusting agents were selected preliminarily, and they are used for dust fall experiments. By comparing the results of the experiment, the rapid penetrant T was selected as the main component of the dust reagent. Then, we use rapid penetrant T to carry out optimized experiment, the best combination for dust removal was selected as the compound and the compound was applied to the site of fully mechanized excavation face. It is found that the use of reagent for dust suppression by spraying can improve the efficiency of dust removal.