Abstract: According to the phenomenon of dust deposition in the dust removal pipeline, a deposition-rebound model of dust in the dust removal pipeline is established. And based on computational fluid dynamics, with the standard k-ε model, Gambit and Fluent fluid calculation softwares are encapsulated by VB.NET. The parameterized calculation software of dust deposition for dust removal pipeline is worked out. The influence of wind speed and dust particle size on the dust deposition is calculated by the software. The results show that the greater the wind speed is, the farther the dust deposition is from the suction outlet. When the dust air reaches to 16 m/s above, dust deposition rate is reduced to 5×10^-5 mm/s. The larger the dust particle size is, the higher the dust deposition rate is, and the closer the maximum dust deposition location is to the suction port, when the dust particle size is 90 um, the maximum dust deposition rate reaches to 6×10^-4 mm/s.