Abstract: In order to effectively control the natural fire and to guarantee safety of the fully mechanized working face under low advancing speed, the cause of spontaneous combustion in goaf of 21170 fully mechanized mining face in Changcun Coal Mine is analyzed based on the spontaneous combustion mechanism of goaf. The technical scheme for comprehensive control of natural fire based on “controlling air leakage and inhibiting residual coal”, that is reducing the air volume of the working face, blocking the air leakage channel and balancing pressure ventilation to reduce the air leakage intensity in the goaf, as well as the spontaneous combustion of coal in the goaf and nitrogen injection for residual coal, is proposed and implemented. From the practical application results of spontaneous combustion in 21170 working face of Changcun Coal Mine, it can be seen that the measures are in accordance with the reality. The concentration of carbon monoxide in the working face decreased to less than 24×10^-6, which effectively controls the spontaneous combustion of the goaf.