Abstract: In recent years, with the mining depth of Shendong Mining Area gradually shifting from the shallow to the middle deep, the mining of the close distance medium-thick coal seam has become more common, and the low oxygen concentration in working face is a new problem in mine production. Through the analysis of the causes of low oxygen content in the working face of the close coal seam group, this paper proposed the corresponding control measures. In order to adjust the pressure difference between the working face and the goaf, the amount of harmful gas emission in the goaf can be reduced by applying pressure equalization and pressure relief ventilation technology in the working face. Finally, this paper analyzes and compares two kinds of low oxygen control and ventilation technologies, and finds out the technical means for the low-oxygen prevention and control of mining close coal seam in Shendong Mining Area.