Abstract: Aiming at the stability problem of slope for the transiton from open-pit to underground mining under double stress, taking the northern side slope of a large opencast coal mine as the research object, the response analysis of the slope under different working conditions and dynamic underground mining were carried out by means of numerical simulation and stability evaluation. Midas Nx finite element software is applied to simulate the central part of the northern margin of the coal mines, which has a great influence on mining production and safety in the target area. The dynamic response of the slopes was analyzed respectively considering the different depth of No.4 and No. 9 coal. The results show that the existence of goaf will reduce the safety factor of slope and cause the stress redistribution of overlying strata in goaf, which will cause deformation and failure of overlying rock mass and affect the stability of slope. The degree of influence on the slope is related to the size and location of the goaf. It is also important to determine the location of the mining side slope for slope stability and resource recovery rate.