Abstract: Based on the theory of fluid mechanics, a turbulent REGK-ε mathematical model for ventilation of wind tunnel in Qiuci Mining air shaft is established. The boundary conditions of the model are determined by analysis. Combined with the actual situation, the three-dimensional flow field in Qiuci Mining wind tunnel is simulated by FLUENT software respectively under different air volume and air inlet and return conditions. The flow field laws of the typical section of the wind tunnel under different conditions are obtained. The pressure loss and wind resistance of the air inlet of the main ventilator are analyzed. The simulation results show that the quantity of air flow coefficient in the first linear relationship between wind resistance and air volume is less than 10^-6, and the wind resistance is visualized as a fixed value. The wind resistance of different fans is different in positive pressure and negative pressure ventilation.