Abstract: Aiming at the problems of the large deformation of the surrounding rock and the failure of the anchor cable in 141712 transportation uphill of a mine in Guizhou Province, the field deformation, failure analysis, laboratory analysis, numerical simulation and other methods were used to analyze the deformation and failure mechanism of surrounding rock in soft rock roadway, and the grouting support technology was proposed. The supporting principle of “bolt + anchor cable + grouting + double U-shaped steel” was designed. Finally, the control scheme of the design was verified by theoretical calculation, numerical simulation, and industrial test. The research shows that: the low strength of surrounding rock, poor self-stability, high stress and complex stress environment, support material support resistance bottom and no support for key parts are the main reasons for deformation and damage of roadway surrounding rock; after adopting the designed support scheme, the deformation of surrounding rock is reduced by 35% to meet the requirements of field application.