Abstract: Based on the importance of similar simulation tests for geological research, quartz sand, lime and gypsum are used as the proportioning materials. The combination of orthogonal design and range analysis is used to control the ratio of sand-to-gel, the ratio of lime to gypsum and the number of curing days. The influence of various factors on the sensitivity of mechanical parameters of similar materials is studied. The results show that the effect of sand-to-gel ratio on the density of the material is greater than that of the lime-to-gypsum ratio. The compressive strength decreases significantly with the increase of the sand-to-gel ratio, and decreases slowly with the increase of the lime-to-gypsum ratio. The effect of curing days against compressive strength is between the two, and the intensity tends to be stable with the increase of time. Through the multiple linear regression analysis of the test results, the test equations of similar proportioning materials were determined, and the roughly determined proportioning materials were adjusted by the number of curing days to make the most reasonable similar materials.