Abstract: To solve the problems of large deformation and supporting difficulties in soft rock roadway in strongly weathering zone, and taking the soft rock roadway along the wind oxidation zone edge of No. 7 coal seam in a mine as the engineering background, the causes of deformation and instability of roadway surrounding rock are summarized according to the characteristics of deformation and failure. Based on the above analysis, we propose the design scheme of strengthening support with the shed for the excavated roadway, and design the roadway section as rectangle for the non-excavated roadways, and adopt the combined support mode of bolt-mesh as the basic support in roadway + strengthening support with the shed + shotcrete. The industrial test shows that the optimized support scheme can effectively control the deformation of surrounding rock and maintain the roadway long-term stability, which effectively solves the problem of large deformation and difficult support in strongly weathering zone.