Abstract: To study the distribution law of coal spontaneous combustion zone in goaf of two intake and one return ventilation working face, the oxygen concentration under different working conditions during the mining of the 8301 working face of Tashan Coal Mine was simulated, the danger zone of spontaneous combustion of coal was determined and corresponding fire prevention measures were proposed. The spontaneous combustion danger zone of coal in the goaf of two intake and one return ventilation working face is large, and the spontaneous combustion zone reaches 96 m when the mining distance is 150 m; nitrogen injection can greatly change the distribution of spontaneous combustion zones and reduce the spontaneous combustion of coal in the goaf. For the two intake and one return ventilation working face, nitrogen injection should be considered on both sides of the goaf; increasing air volume allows the boundary of the spontaneous combustion zone to extend deep into the goaf and increase the distance of the front end from the working face.