Abstract: To prevent and cure clay clogging in grouting pipelines of coal mine water control, experiments and practices on softening clay clogging in grouting pipelines of coal mining were studied. The clogging characteristics of clay grouting pipelines had been analyzed. A group of disintegration tests under different clay softeners as well as the mechanisms had been studied. The results show that chemical reaction of strong oxidizer is the most intense, acidic softener the second, and alkaline softener is the weakest. The 0.1 mol/L amino sulfonic acid solution or 0.25 mol/L acetic acid solution is best softener. Coal mine practice has effectively prevented clay grouting pipeline clogging by applying epoxy resin, monitoring the pressure of key parts and putting softener into the clogging parts.