Abstract: By using FLAC^3D software, the slope numerical model of anchorage open-pit mine is established, and the influence of anchorage parameters on dynamic response of bolt, displacement response of slope and plastic strain through length of slope is studied, and the sensitivity of anchorage parameters is analyzed by weight analysis method. The results show that with the increase of bolt length and anchor hole diameter, the permanent horizontal displacement of slope and the penetration rate of plastic strain zone decrease, and the axial force peak of bolt increases gradually. With the increase of vertical spacing of bolt, all three increase. With the increase of anchoring inclination angle, the permanent horizontal displacement of slope and the plastic strain area first decrease and then increase, and the peak axial force of bolt first increases and then decreases. The weight of anchorage parameters on bolt axial force is in order from high to low: anchor hole diameter, bolt length, bolt spacing, anchor inclination angle. The weight of influence on penetration rate of plastic strain zone is the bolt spacing, anchor hole diameter, bolt length and anchor inclination angle successively from high to low. The weight of influence on slope displacement from high to low is bolt spacing, bolt length, anchor hole diameter and anchor inclination angle.