Abstract: To improve the ventilation efficiency of mine engine station, aiming at the minimum local resistance coefficient of engine station, the orthogonal numerical simulation test was carried out by selecting four influencing factors including diffusion angle of engine station, roadway length in air inlet, contraction angle and roadway length in air outlet and setting reasonable levels. The results show that the main and the secondary factors affecting the local resistance coefficient of the machine station are diffusion angle, contraction angle, tunnel length in the inlet and the tunnel length in the outlet. With the change of roadway wind speed, the optimal structural parameters of the station are different. When the roadway wind speed is 1.2 m/s to 1.5 m/s, the optimal combination of the structure is 60° diffusion angle, 30° contraction angle, 9 m of roadway length in the inlet section and 6 m of roadway length in the outlet section. When the wind speed is 1.5 m/s to 2 m/s, the local resistance coefficient of 10 m station is selected as the roadway length in the wind outlet section.