Abstract: The basic requirements for the protective sealing door(wall), transition chamber, living room, emergency exits and other structure of refuge chamber are presented in this paper. The refuge chamber should have all or part of functions of safety protection, oxygen supply, removing harmful gas, temperature and humidity control, environmental monitoring, lighting, communication, life support, and meet the corresponding requirements. In the process of the refuge chamber design, the targeted design calculation and scheme optimization should be carried out according to the specific conditions.