Abstract: In order to realize the transition of safety decision from experience-driven to data-driven and improve the effectiveness of safety management, the connotation of best safety evidence was discussed based on evidence-based safety(EBS) management theory,and a safety management mode optimized by best safety evidence was proposed. On this basis, EBS management system of gas explosion accidents was established, and the safety decision based on best safety evidence was proposed by taking time data of gas explosion accidents as the research object. The results show that the application of EBS management in production field can optimize the current safety management mode, bridge the gap between safety research and safety practice, and improve the pertinence of safety decision. This study was the first attempt of EBS theory in specific production field, which also provides feasible ideas for the research, practice and development of EBS management.