Abstract: In order to study the stability of backfill under the influence of mine water, a sulfate-chlorine salt compound solution was prepared to simulate the erosion effect of mine water. At the same time, considering the different limestone contents in different cementing materials, the stability of backfill specimens with different limestone contents in different erosion solutions was also studied. The cured specimens were soaked in sulphate and sulphate-chloride solutions for 24 months for appearance observation, quality measurement and compressive strength test. The results show that the deterioration of specimens soaked in different salt solutions occurred after 5 months. The higher the content of limestone in the specimen is, and the more vulnerable to the erosion of sulfate is. At the same time, it is also found that when sulfate and chloride exist at the same time, chloride can prevent sulfate from eroding the specimen of filling body, thus greatly slowing down the deterioration of filling body.