Abstract: As a high-gas coal mine, gas accidents in Chengzhuang are mainly occurred in geological structure affected area, which seriously affect the safety production of the mine. After research and practice, the paper develops the comprehensive gas control measures which combine drainage hole by drilling machine construction with advanced detection hole in geological structure affected area. The implement of comprehensive gas control measures effectively solve the gas abnormal problems in geological structure affected area, which has been promoted in the heading face of mine.