Abstract: In view of the serious situation of water disaster prevention and control of the roof and floor of a coal mine in Zhunger Mining Area, a single detection technology is not enough to meet the current water control requirements. A comprehensive exploration technology is proposed to preliminarily delineate the abnormal area by underground audio frequency electric penetration and slot wave seismic exploration technology, and to explore the abnormal area by geochemical water quality test technology combined with directional drilling technology. Using the comprehensive exploration technology, a low resistivity abnormal zone and a strong attenuation area of trough wave energy were delineated in a working face of the mine. The directional drilling technology was used to drill the delineated abnormal area. The water quality test data showed that the Cl- content in the water from the directional drilling was significantly higher than that in the conventional roof sandstone water, and 457.5 t cement slurry was injected. The actual exposure results show that the area is a geological abnormal body and the stratum is disordered. There is no water conducting phenomenon of Ordovician limestone water in the working face. The cement sample can be seen in the core drilling, which indicates that the grouting cement has effectively cemented and solidified the broken stratum. The safe mining of the working face shows the feasibility of comprehensive exploration and prevention technology in the field of water disaster prevention and control.