Abstract: Aiming at the problems of faults, precipitation, weak layers and other factors inducing the deformation and instability of the end slope of the open-pit mine, taking the north slope of Dongming Open-pit Mine as the engineering practice background, the method of combining numerical simulation theory and limit equilibrium analysis is used. The influence of the weak layer of the north side slope on the deformation and displacement law of the slope rock and soil, and at the same time, combined with the limit equilibrium analysis method to control the stability of the north side slope, two schemes are proposed, namely, slope cutting and load reduction + pressure reduction. Through analysis and research, and based on the calculation results of Geo-slope and engineering geological conditions, the plan of slope cutting and load reduction + presser foot is finally adopted, which provides a reference for safe and efficient production during actual mining.