Abstract: In order to solve the problem that the surface geophysical prospecting method has insufficient resolution ability in mine geological structure and hydrogeological exploration, to understand the development of small fault structure and water conduction characteristics in fully mechanized mining face, and to guide mine safety production, the comprehensive mine geophysical prospecting method is used to carry out geological prediction research on the same working face. In two roadways with the same working face, using the perspective channel wave seismic exploration technology and the radio wave perspective method, the bilateral fine exploration of faults and collapse columns in the working face with a length of 1 050 m and a width of 195 m was carried out, and the results of seismic velocity distribution of channel wave and attenuation coefficient of radio wave transmission were obtained. The water-bearing structure in the working face was investigated by mine TEM. Combined with the known geological information, the comprehensive interpretation and reliability analysis of the anomalies delineated by the three kinds of mine geophysical exploration methods are carried out, and finally three concealed faults and five water-bearing faults are explained. The two known collapse columns do not conduct water, but there are water-bearing areas nearby, and there is the possibility of conduction in the process of mining. All the small and medium-sized structures exposed have geophysical anomalies. The exploration results have been verified by drilling and mining, and the verification rate reaches 80%. Studies have shown that the mine geophysical prospecting geological target body can make full use of the working face roadway on both sides of a single method of bilateral joint detection because of the distance is near, so, the fine exploration of small and medium faults with a fault distance less than 2 m can be realized. But, the interpretation of geophysical anomaly areas inferred by single mine geophysical prospecting method is often affected by the method itself and the working environment. According to the physical property difference of geological task and geological target body, several suitable geophysical exploration methods are selected for joint exploration, and multi-parameter comprehensive interpretation combined with geological data can realize effective exploration of small and medium-sized geological abnormal body in mine.