Abstract: Aiming at the problem of sensor layout in large-scale physical three-dimensional simulation experiment of safe co-mining of coal and gas, through numerical simulation, theoretical analysis, we find the key information points of gas migration and compressive stress changes, optimize sensor layout parameters, and improve similarity simulation similarity and collection efficiency. First of all, we establish the gas and compressive stress distribution map through numerical simulation, and analyze the key point information of changes in the distribution law. And then, we use this location point information to establish time-divided and selective data collection plan, and a distributed communication collection board was designed to realize a dynamic area data collection system per unit time and reduce the amount of data collection per unit time. Finally, the sampled data was processed by the differential value, the influence of different wind speeds on gas migration was obtained and the gas enrichment area at 60 m was inferred. At the same time, the vertical stress distribution at various stages along the coal seam strike was established. By comparing the data with the microseismic monitoring results, the results agree with each other.