Abstract: Mining is one of the key safety production industries that are seriously affected by earthquake disasters and prone to disasters. After many earthquakes such as “Tangshan earthquake” and “Wenchuan earthquake”, there have been serious disasters such as shaft and roadway engineering damages and sharp increase in water inflow, resulting in varying degrees of casualties and economic losses. Aiming at the lack of impact assessment methods of earthquake-induced coal mine secondary disasters, based on the theories of earthquake disaster, safety engineering and system science, and taking the mine lifeline system as the main line, this paper studies and proposes a comprehensive impact assessment method of earthquake-induced coal mine secondary disasters, which is as follows: firstly, the possibility of earthquake-induced coal mine secondary disasters in coal mines is evaluated from the level of earthquake disasters in the area where the mine is located, the risk of earthquake-induced coal mine secondary disasters, the disaster caused by coal seam gas occurrence, the disaster caused by hydro-geological conditions, and the standard setting of earthquake disaster bearing body; secondly, the severity of the consequences of earthquake-induced coal mine secondary disasters is evaluated from three aspects: casualties, economic losses and social impact of disasters; finally, the risk level of coal mine disaster induced by earthquake is determined by constructing the risk level matrix of mine disaster bearing body. The assessment method covers many factors, such as the current situation of pre-disaster fortification, the level of earthquake disaster at the time of disaster, the ability of post disaster emergency disaster reduction and relief, and realizes the full coverage of all key influencing factors before, during and after disaster.