Abstract: According to the problems of the one-winged concentrated production and excessive ventilation resistance in the late period of Liangjia Coal Mine. By determining the ventilation resistance of the mine ventilation system, the present ventilation resistance distribution conditions of this mine were analyzed. Hereby, the mine ventilation system optimization scheme was provided. It carried out the network solution analysis for each scheme with the computer, on the basis of meeting the mine safety production requirements, by comparing the economic and technical aspects, it determined the optimal reform scheme of mine ventilation system.