Abstract: In view of the difficulty of professional management of “one ventilation and three prevention” to meet the demand of daily intelligent control of mine, the paper proposes to build an intelligent control system for one ventilation and three prevention in mines. Based on the core technologies of Internet of Things, big data, information technology and computer intelligent algorithm, the intelligent control system is established, and a collaborative operation mode with Internet of Things and computer intelligent algorithm is built. Based on this, the intelligent control system of “one ventilation and three prevention” is developed, the main functions of the system include intelligent optimization analysis and assistant decision of mine ventilation network, intelligent control of mine dust, gas analysis early warning and intelligent control, coal spontaneous combustion monitoring and early warning and intelligent control as well as mine external fire monitoring and early warning and intelligent control. The intelligent system integrates monitoring, analysis, decision-making and control, and realizes intelligent control of “one ventilation and three prevention” in mines, which can effectively ensure mine safety and provide important technical support for the intelligent construction of coal mines.