Abstract: The mining disturbance between multiple working faces will induce rock burst disaster, and regional harmonic mining is one of the key means to prevent this kind of rock burst. In order to verify the rationality and effectiveness of regional harmonic mining to prevent rock burst, taking Yima Mining Area where rock burst occurs frequently as an example, based on the harmonic mining principles and parameter values obtained from simulation, the harmonic mining scheme in the area between Yuejin and Changcun coal mines is formulated, and the effect of harmonic mining is evaluated by comparing the stress transfer characteristics and rock burst characteristics in the area with different harmonic degrees. The results show that the thickness of coal seam and huge thick conglomerate of Yuejin 23092 face and Changcun 21162 face are smaller in the area between Yuejin and Changcun coal mines. The width of coal pillar between 23092-21162 and 21170-21162 working faces are larger, and the horizontal distance and vertical offset between the two faces are further, so the 23092 and 21162 working faces between the two coal mines are the optimal continuous working faces. The degree of harmonic mining in the area between Yuejin and Changcun coal mines is higher than that of Gengcun and Qianqiu coal mines. The frequency and intensity of stress transfer caused by rock burst and mining among working faces are all significantly reduced with harmonic mining, and the range of stress transfer significantly is reduced, so the effect of harmonic mining is obvious.