Abstract: The characteristics of multi-disaster symbiosis and coupling, such as rock burst, gas and spontaneous combustion, are presented in the process of deep mining. There are induced, transformed and coupled correlation phenomena among disasters, and the disaster causing mechanism is complex. The single control and prevention measures of different disasters belong to different departments which lead to the poor synergy effect of management measures and the lack of targeted technical methods. Based on this, the present situation of rock burst multi-disaster symbiosis and disaster causing is discussed, and the concept of rock burst multi-disaster and disaster compound mode are proposed. Combined with the hydraulic measures used in disaster management and their temporal and spatial relationships, a multi-disaster cooperative prevention method of “drilling-hydraulic cutting-hydraulic fracturing-gas drainage-inhibitor solution injection” for rock burst coal seam was proposed, and the industrial test was carried out in 6304 working face of Tangkou Coal Mine. Through the sequence of drilling, hydraulic fracturing, hydraulic fracturing, gas extraction, coal seam water injection, pressure injection inhibitor and other technical measures, the effective release of local high stress, the change of mechanical properties of coal rock, the significant improvement of coal permeability, the increase of moisture radius of coal body water injection and the increase of coal body water content are realized, and the risk of coal spontaneous combustion is reduced. Coordinated disaster prevention and control has been achieved.