Abstract: Aiming at the characteristics that large dangerous area of spontaneous combustion, serious air leakage and high concealment of fire source for inflammable thick coal seam with large inclination, according to the actual condition of the mining face in inflammable thick coal seam of a coal mine, the index gas of coal spontaneous combustion prediction was determined through the oxidized heating experiment for coal samples. Combined with the analysis of spontaneous combustion law of inflammable thick coal seam with large inclination, the comprehensive prediction and control technology was established, including spontaneous combustion prediction technology, advance inerting technology of working face, goaf inerting technology and fast processing technology of fire area, which effectively ensured the safe and efficient mining for the mining face of inflammable thick coal seam with large inclination.